“The drugs do work!” cry the headlines. But read the full report and the picture is rather different…

“Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults.” If you read the news recently following the publication of the report on Anti Depressants ( Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis ), you would be forgiven for thinking this was the final word on the issue. The message was clear: the drugs work and millions more should be taking them. But delve into this thoughtful, measured report and the picture is far less clear. The writers recommend caution in drawing conclusions due to the “paucity of information reported in the original studies” and “a [possible] bias in conduct, analysis, or reporting of head-to-head trials, driven by commercial interests”. They note that whilst “depressive symptoms tend to spontaneously improve over time” for more persistent depression antide...